Common uses

The drug Motilium contains active ingredient Domperidone. It is ant-emitic, dopamine antagonist type of drug. The main purpose of Domperidone is to treat nausea and vomiting, also it can be used to treat fullness, abdominal fullness, bloating and discomfort.

The mechanism of this medicine is based on blocking certain dopamine receptors in brain chemoreceptor trigger zone (CTZ). It effectively blocks vomiting reflex and stop nausea.

Before using

Consult your doctor before using this medicine. Take greater concern in case of following:

Allergic reaction to Domperidone.

Pregnancy - there are no studies of Domperidone in pregnant women, but no birth defects have been detected in animal test.

Breastfeeding - domperidone passes into women milk, but there is no information of possible negative effects. Be sure to consult your doctor before taking domperidone.

Children - domperidone was not studied in children, but there is no specific information about possible harm.

Consult your doctor before taking this medicine if you have bowel problems, bleeding from stomach, liver disease.

Dosage

Noraml dose of domperidone is 10mg 3-4 times a day, 20-30 min before meals or at bedtime. The dose can be increased to 20mg 3-4 times a day.


Possible side effects

Domperidone is not recommended for long term use.

Take note that Motilium contains lactose and may be not suitable for people with intolerance to lactose. Possible side effects of domperidone can include the following: diarrhoea, breast pain, stomach cramps, abnormal enlargement of breasts in men, abnormal movements legs, face, hands, neck and tongue, eg tremor, twitching, rigidity (extrapyramidal effects).

Overdose

If you take to much symptoms of evrdose can include disorientation, drowsiness and extrapyramidal reactions. Anti-parkinson or anticholinergic may be helpful in these situations.


Drug interactions

Drugs that can interact with domperidone are following:

• nefazodone
• "azole" antifungals ( itraconazole, fluconazole, ketoconazole, miconazole)
• erythromycin antibiotics (clarithromycin)
• MAO inhibitors (phenelzine)
• HIV protease inhibitors (indinavir)

Consult your doctor to decide how you can combine those taking those drugs together with domperidone.

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When it comes to digestive health, the condition you're most likely to suffer from is constipation. In constipation, infrequent bowel movements cause hard stools that are difficult to pass. You're most likely to struggle with irregular bowel movements if you are an older adult or pregnant, but lifestyle factors, such as a low intake of fiber and fluid or limited activity, also slow bowel transit. Constipation isn't just uncomfortable though, as infrequent bowel movements can signal a medical problem. Here are three reasons to visit your doctor if you suffer from chronic constipation.

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If you have poor blood sugar control, you may experience damage to the nerves that control your digestive tract, which can present as constipation, diarrhea, nausea and heartburn. Known as autonomic neuropathy, this type of nerve damage is usually seen in more advanced cases of diabetes, arising from late diagnosis of diabetes or poor compliance with blood glucose control. Input from your doctor, diabetes nurse and dietician can help you achieve better glycemic control and preserve nerve function. Signs of poor blood sugar control include increased thirst, urination and tiredness, recurrent thrush, poor wound healing, weight loss and blurred vision, so these symptoms should always be reported to your physician.

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Constipation is sometimes a symptom of Parkinson's disease, where damage to the brain cells that produce the chemical dopamine affects your muscle function. While tremors, slowed movement and muscle stiffness are common signs of Parkinson's disease, the muscles of your digestive system can also be affected, making them operate slower, which causes constipation. Although medications to treat Parkinson's disease ease symptoms, constipation is a possible side effect of certain drugs to manage this neurological condition.

Infrequent bowel movements are also seen in multiple sclerosis. Constipation may occur as a symptom of multiple sclerosis, as the disease disrupts nerve signals to empty your bowels, stops your pelvic floor muscles relaxing and interferes with your natural urge to visit the bathroom after eating. If you experience altered bowel habits alongside tingling, numbness, poor balance, limb weakness or blurred vision, you should seek medical advice, as this combination of symptoms may suggest multiple sclerosis.

Although changes to dietary intake and exercise habits can help to ease constipation, persistent problems with your bowels require a medical assessment to rule out a more serious cause. Therefore, always book an appointment with your doctor to investigate constipation, particularly if it occurs alongside other new symptoms.

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